Abstract
The reactivity of simple epoxides with 4-( p-nitrobenzyl)-pyridine was compared with their mutagenicity in Salmonella typhimurium TA 100 and Escherichia coli WP 2 uvrA. The order of reactivity correlated well with mutagenicity, trichloropropylene oxide being most potent followed by epichlorohydrin, styrene oxide, glycidol and propylene oxide. The results suggest that 4-( p-nitrobenzyl)-pyridine alkylation is a simple and reliable primary assay in the evaluation of mutagenic properties.
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