Correlation of miR-425-5p and IL-23 with pancreatic cancer.

Abstract

The aim of this study was to detect the levels of miR-425-5p and IL-23 in tissues of pancreatic cancer patients and to explore their effects on pancreatic cancer. A retrospective analysis of 76 cases of pancreatic cancer tissue specimens and normal fresh tissue specimens at 50 mm adjacent to the corresponding cancer surgically resected in the first diagnosis was performed, in the Department of Radiotherapy of Traditional Chinese Medical Hospital of Huangdao District and Weifang Medical University Hospital from October 2015 to October 2016. RT-qPCR was used to detect miR-425-5p levels in pancreatic cancer and adjacent tissues, and ELISA to detect IL-23 levels in the tissues. The correlation of miR-425-5p and IL-23 in pancreatic cancer tissues with clinicopathological parameters was analyzed. The expression levels of miR-425-5p and IL-23 were significantly higher in pancreatic cancer tissues than those in adjacent tissues, with statistically significant difference (P<0.001). The expression level of miR-425-5p was positively correlated with IL-23 in pancreatic cancer tissues (r=0.432, P<0.001), and of miR-425-5p in tumor tissues of pancreatic cancer patients was correlated with lymph node metastasis, clinical stage and differentiation degree (P<0.001). That of IL-23 in tumor tissues of pancreatic cancer patients was correlated with clinical stage (P<0.001). The expression levels of miR-425-5p and IL-23 in tissues of pancreatic cancer patients are higher than those in adjacent tissues. The expression level of miR-425-5p is positively correlated with that of IL-23 in pancreatic cancer tissues, and that of miR-425-5p in tumor tissues of pancreatic cancer patients was correlated with lymph node metastasis, clinical stage and differentiation degree. IL-23 in tumor tissues of pancreatic cancer patients was correlated with clinical stage. miR-425-5p and IL-23 may be involved in the pathological development of pancreatic cancer.