Abstract
Objective To investigate the expression of tripartite motif 14 (TRIM14) in pancreatic cancer tissue and its clinical significance. Methods The expression of TRIM14 in 32 specimens of pancreatic cancer tissue and 32 specimens of adjacent normal tissues was detected by immunohistochemistry and Western blotting, and their correlation with clinicopathological features of pancreatic cancer was analyzed. Results As compared with adjacent tissues, the expression of TRIM14 protein was up-regulated in pancreatic cancer tissues (t=19.520, P 0.05), but significantly correlated with clinical stage, differentiated degree and tumor size (P<0.05). The survival time in patients with high TRIM14 expression was significantly shorter than that in patients with low TRIM14 expression (χ2=5.180, P<0.05). Conclusion The positive TRIM14 expression rate is increased in pancreatic cancer tissue, and its positive expression may be associated with the occurrence, development and invasion of pancreatic cancer. The TRIM14 expression predicts a poor prognosis in patients with pancreas cancer. Key words: Pancreatic neoplasms; Tripartite motif 14; Prognosis
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