Abstract
Correlation of Leptinemia with Components of Metabolic Syndrome in Youths: Influence of Obesity, Gender and Stage of Puberty
Highlights
Methods and ProceduresThe rising worldwide epidemic of obesity in adults and pediatric population (42 million children under the age of 5 overweight or obese)[1,2,3,4] is quite alarming, since obesity, is associated with metabolic disorders, such as glucose intolerance and Insulin Resistance (IR), which are risk factors for Cardiovascular (CV) disease and mortality[5,6,7]
Hyperleptinemia an indicator of leptin resistance may cause IR and β-cell dysfunction increasing the risk of T2DM and it may play a role in the development of HTN and HTN-related end-organ damage, as well as obesity-associated CV disease[16,17,18]
There was an association of obesity with several components of Metabolic Syndrome (MetS), including high levels of Blood Pressure (BP), insulin, IR, total-cholesterol, TG, leptin, ALT and UA, and lower levels of HDL-cholesterol
Summary
The rising worldwide epidemic of obesity in adults (more than 1.9 billion overweight, over 600 million obese) and pediatric population (42 million children under the age of 5 overweight or obese)[1,2,3,4] is quite alarming, since obesity, is associated with metabolic disorders, such as glucose intolerance and Insulin Resistance (IR), which are risk factors for Cardiovascular (CV) disease and mortality[5,6,7]. Hyperleptinemia an indicator of (selective) leptin resistance may cause IR and β-cell dysfunction increasing the risk of T2DM and it may play a role in the development of HTN and HTN-related end-organ damage, as well as obesity-associated CV disease[16,17,18]
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