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Abstract

Arisaka et al summarize results from a community-based cohort of children aged 9-10 years showing high correlations of 5 important clinical lipid/lipoprotein indices—total cholesterol:high-density lipoprotein cholesterol (HDL-C), triglyceride:HDL-C, non–HDL-C, triglycerides, and apolipoprotein B—with low-density lipoprotein (LDL) particle size. These laboratory results support the hypothesis generated in our epidemiologic study that non–HDL-C is associated with metabolic syndrome in youth. The association could be explained, at least in part, by reduced LDL particle size. A previous review has shown that LDL particle size and number are correlated with the risk of cardiovascular diseases.1Superko H.R. Gadesam R.R. Is it LDL particle size or number that correlates with risk for cardiovascular disease?.Curr Atheroscler Rep. 2008; 10: 377-385Crossref PubMed Scopus (72) Google Scholar Future research is warranted to identify the biochemical mechanisms responsible for the associations between lipid/lipoprotein indices and LDL particle size and number. Arisaka et al summarize results from a community-based cohort of children aged 9-10 years showing high correlations of 5 important clinical lipid/lipoprotein indices—total cholesterol:high-density lipoprotein cholesterol (HDL-C), triglyceride:HDL-C, non–HDL-C, triglycerides, and apolipoprotein B—with low-density lipoprotein (LDL) particle size. These laboratory results support the hypothesis generated in our epidemiologic study that non–HDL-C is associated with metabolic syndrome in youth. The association could be explained, at least in part, by reduced LDL particle size. A previous review has shown that LDL particle size and number are correlated with the risk of cardiovascular diseases.1Superko H.R. Gadesam R.R. Is it LDL particle size or number that correlates with risk for cardiovascular disease?.Curr Atheroscler Rep. 2008; 10: 377-385Crossref PubMed Scopus (72) Google Scholar Future research is warranted to identify the biochemical mechanisms responsible for the associations between lipid/lipoprotein indices and LDL particle size and number. Fasting non–high-density lipoprotein cholesterol and low-density lipoprotein particle sizeThe Journal of PediatricsVol. 160Issue 3PreviewLi et al1 reported that the fasting concentration of non–high-density lipoprotein cholesterol (HDL-C), calculated as the difference between total cholesterol (TC) and HDL-C levels, is strongly associated with metabolic syndrome (MetS) in youth in the United States. Screening for MetS based on non–HDL-C concentration has an advantage in the pediatric setting because pretest fasting is not required.2 Dyslipidemia in MetS is characterized by elevated triglyceride (TG) concentration, decreased HDL-C concentration, and reduced low-density lipoprotein (LDL) particle size. Full-Text PDF