Abstract
Background Intracranial atherosclerosis (ICAS) is one of the major risk factors for ischemic stroke. Presence of carotid plaque is related to subsequent stroke. However, the correlation between this and ICAS is less clear. Methods We retrospectively evaluated 2,560 adults who voluntarily visited a general hospital for a health screening examination that included brain magnetic resonance angiography and carotid duplex ultrasonography. ICAS were defined as a reduction in luminal diameter of at least 50% or occlusion. Carotid plaque was defined as a focal carotid intima-media thickness of >1.5 mm. Results ICAS was identified in 30 subjects (1.2%). Moderate to large plaques were detected in 286 subjects (11.2%). Compared with those without ICAS, the subjects with ICAS were older (63.6±11.65 vs. 56.5±10.25 years; p<0.001) and had higher fasting glucose (113.7±32.74 vs. 100.8±25.96; p=0.007), blood urea nitrogen (14.0±4.34 vs. 11.5±3.88; p<0.001), creatinine (0.85±0.23 vs. 0.76±0.19; p=0.019), HbA1C (6.3±1.20 vs. 5.9±0.90; p=0.01), and more with plaques (70.0% vs. 26.6%; p<0001). After adjusting for confounding factors, the presence of plaques was significantly associated with ICAS. Conclusion The results suggest the presence of carotid plaques is independently correlated with ICAS. Key words: Carotid arteries; Plaque, Atherosclerotic; Intracranial atherosclerosis
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