Correlation of Interleukin-10 and Interleukin-8 with Cytomegalovirus and Epstein–Barr Virus Infection in Hemodialysis Patients

Abstract

Abstract Background: Herpes viruses like cytomegalovirus (CMV) and Epstein–Barr virus (EBV) can cause serious illness in those who already have impaired immune systems. Objectives: The purpose of this research was to examine the impact of CMV and EBV infection on specific immunological markers in individuals undergoing hemodialysis. Materials and Methods: Blood sample was collected from 91 hemodialysis patients and 50 healthy individuals as a control group for comparison. Serum was separated and examined for the confirmation of CMV and EBV infection, and then the sera was tested by using specific ELISA kits (human interleukin-10 and human IL-8, Sunlong Biotech Co., HangZhou, China). Results: Highest mean of IL-8 and IL-10 was obtained in CMV IgM positive patients in comparison with IgG positive and control group with P value = 0.00002, 0.0008, respectively. The results in patients with EBV IgM positive were also highly significant in comparison with control, P value for IL-8 was 0.0002 and for IL-10 was 0.00004. Conclusion: The study concluded that, the level of IL-10 and IL-8 was higher among hemodialysis patients with acute EBV and CMV infection, and this indicated that the ability of CMV and EBV to enhance IL-8 and IL-10 production which may play an important role in immune inflammatory states associated with CMV and EBV infection.