Abstract
Background: Brain tumors contribute significantly to morbidity as they can lead to neurological deficits, mental alterations and have a poor survival rate. The utmost frequent varieties of primary brain tumors are gliomas. Modern data on permeated gliomas showcased persistent modification within the involved genes in the chromatin remodeling routes such as α-thalassemia/mental-retardation syndrome-X-linked gene (ATRX) and IDH1. Till date, the authenticity of ATRX in predicting isocitrate dehydrogenase (IDH1) mutations in gliomas, is unclear. This study attempts to assess the correlation between IDH1 mutation and ATRX expression and histopathological grading in glial tumors.
 Methods: This will be a retrospective analytical study conducted in Pathology Department, of JNMC, Wardha in coordination with the Department of Neurosurgery, AVBRH. This study will include histochemical analysis of 45-50 resected specimens of confirmed cases of Glial tumours. The correlation between IDH1 mutation and ATRX expression with the histopathological grades in glial tumors will be analysed in comparison with the present-day molecular advances.
 Results: Significant correlation between IDH1 mutation and ATRX expression with the histopathological grades is expected.
 Conclusion: Conclusion will be drawn on careful analysis of data.
Highlights
The central-nervous-system is made up of the brain & the spinal cord and their coverings
Brain tumors contribute significantly to morbidity as they can lead to neurological deficits, mental alterations and have a poor survival rate
The present study aims to close the gap of understanding between correlation between IDH1 mutation and as α-thalassemia/mentalretardation syndrome-X-linked gene (ATRX) expression with the histopathological grades in glial tumors in comparison with the present-day molecular advances
Summary
A Department of Pathology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi (Meghe), Wardha, India. This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/80845
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