Correlation of heart-type fatty acid-binding protein and glycogen phosphorylase enzyme BB in brain with septic myocardial injury

Abstract

The incidence of sepsis is on the rise, and the mortality is also high.Myocardial injury caused by sepsis is one of the important causes of death.However, there is no clear and unified diagnostic criteria to sepsis complicated with myocardial injury.The clinical diagnostic criteria of myocardial injury is mainly based on cardiac ultrasound, myocardial markers and so on.But the measurement of ejection fraction is needed to consider the impact of preload and afterload of left ventricula, also the subjective level of operators.So cardiac markers play an important role in the detection of myocardial injury in sepsis and can reflect the severity of myocardial injury and sepsis, especially in the early diagnosis and prognosis.Heart-type fatty acid binding protein and brain glycogen phosphorylase isoenzyme type exhibit higher sensitivity, specificity and stability compared to other traditional cardiac markers in the clinical diagnosis of myocardial injury, which are worth to be studied and applied in the clinical diagnosis of myocardial injury. Key words: Sepsis; Myocardial injury; Cardiac markers; Heart-type fatty acid binding protein; Brain glycogen phosphorylase isoenzyme type