Changes of serum heart type fatty acid binding protein and brain natriuretic peptide and their clinical significance in children with Kawasaki disease

Abstract

Objective To explore the serum levels changes of heart-type fatty acid-binding protein and brain natriuretic peptide in children with Kawasaki disease, as well as their links with the heart function. Methods A total of 53 children with Kawasaki disease admitted to our hospital from February 2008 to March 2012 were selected and at the same time 50 healthy controls were randomly selected.The serum levels for the children in acute phase, recovery period of Kawasaki disease and control group children were determined by enzyme-linked immnoabsorbent assay.The internal diameter of coronary artery, LVEF, LVSF, CI and E/A of children were measured by two-dimensional echocardiography. Results The heart-type fatty acid-binding protein and brain natriuretic peptide concentrations of children with Kawasaki disease in acute stage[(18.23±13.81) ng/ml,(517.2±213.2) pg/ml]were higher than those in recovery stage[(6.29±1.26) ng/ml,(92.1±46.0) pg/ml](P<0.05). They were also higher for children in acute stage than those of control group[(6.26±1.60) ng/ml,(37.6±7.6) pg/ml]. The LVEF, LVSF, CI of Kawasaki disease for children in acute stage were lower than those in recovery phase[(60.3±3.6)% vs.(64.8±4.3)%,(30.6±2.5)% vs.(34.9±1.9)%,(3.1±0.3)% vs.(3.5±0.3)%]. Linear correlation analysis showed the heart-type fatty acid-binding protein and brain natriuretic peptide′concentrations in Kawasaki disease were negatively correlated with LVEF(P<0.05). The heart-type fatty acid-binding protein′positive rates were also higher than brain natriuretic peptide for the children in acute and recovery phase. Conclusion The heart-type fatty acid-binding protein and brain natriuretic peptide could be used as the biochemical markers for myocardial damage of children with Kawasaki disease.The heart-type fatty acid-binding protein was more significant than brain natriuretic peptide.The heart-type fatty acid-binding protein and brain natriuretic peptide in Kawasaki disease were also high in recovery stage, indicating that myocardial damage could maintain for a long period after the clinical improvement. Key words: Kawasaki disease; Heart-type fatty acid-binding protein; Brain natriuretic peptide