Correlation of Glycated Hemoglobin with Serum Triglyceride to High Density Lipoprotein Ratio in Type 2 Diabetes Mellitus Patients

Abstract

Introduction: Diabetes mellitus is an endocrine disorder characterized by hyperglycemia. It may be due to a defect in insulin secretion or action or both. Importantly, lipid metabolism is also abnormal in diabetes such as an increment of TG level and reduction in plasma HDL level which is the major cardiovascular risk. Glycated hemoglobin is measured to monitor the long-term glycemic status of the patients.Materials and Methods: The current study is designed retrospectively to find out the correlation between HbA1C and TG to HDL ratio. The data onthe lipid profile of newly diagnosed diabetes mellitus were retrieved from the laboratory software of National Medical College, a tertiary care hospital in Madhesh province, Nepal. The categorical data were expressed in frequency and percentage and continuous data were expressed in mean and standard deviation depending on their distribution. Pearson correlation analysis was used to correlate the glycated hemoglobin and TG to HDL ratio. Results: The current study investigated the diabetic and lipid profile in 604 retrospectively enrolled patients. Out of which 358 (59.3%) were diabetic and 246 (40.7%) were healthy subjects.The comparison of serum lipid levels between diabetes and healthy subjects revealed a significant difference concerningTriglycerides, total cholesterol, HDL, LDL, and VLDL (P value less than 0.05). The correlation analysis revealed a significant positive correlation betweenTG/HDL ratio and glycated hemoglobin (0.09, 0.02).Conclusion: Our results revealed the correlation between HbA1C and TG/ HDL ratio in the Nepalese diabetic population. Hypertriglyceridemia was common in diabetic patients. Elevation of the TG/HDL ratio aggravates the cardiovascular risks in the diabetic patients.