Correlation of gene polymorphisms of vascular endothelial growth factor with grade and prognosis of lung cancer

Changjiang Liu,Xuetao Zhou,Zefeng Zhang,Yang Guo

doi:10.1186/s12881-020-01030-0

Abstract

BackgroundVascular endothelial growth factor (VEGF) gene is highly polymorphic, and single nucleotide polymorphisms (SNP) of VEGF gene are associate with cancer prognosis. This study aimed to analyze the correlation of VEGF gene polymorphisms with grade and prognosis of lung cancer.MethodsA total of 458 Chinese patients with primary lung cancer were enrolled from September 2008 to October 2013. The genotypes of −2578C > A, −1154G > A, − 460 T > C, and + 405G > C were analyzed in white blood cells from patients using polymerase chain reaction based restriction fragment length polymorphism.ResultsOur data showed that –1154G > A polymorphism was significantly associated with tumor stages, but all four tested VEGF gene polymorphisms had no significant effect on survival.ConclusionsVEGF polymorphisms may relate to stage of lung cancer in Chinese population.

Highlights

Vascular endothelial growth factor (VEGF) gene is highly polymorphic, and single nucleotide polymorphisms (SNP) of VEGF gene are associate with cancer prognosis
We found that VEGF -1154G > A polymorphism was significantly associated with tumor stages, but all four tested VEGF gene polymorphisms had no significant effect on survival
It is reported that the -1154A/A and G/A genotype were linked with low VEGF expression, and the -1154A/ A polymorphism related with poor vascularization in patients with lung cancer [13]

Summary

Introduction

Vascular endothelial growth factor (VEGF) gene is highly polymorphic, and single nucleotide polymorphisms (SNP) of VEGF gene are associate with cancer prognosis. This study aimed to analyze the correlation of VEGF gene polymorphisms with grade and prognosis of lung cancer. Conclusions: VEGF polymorphisms may relate to stage of lung cancer in Chinese population. The vascular endothelial growth factor A (VEGF-A) has been well identified as one of the key regulators of this process [4, 5]. Clinical studies have revealed that the VEGF-A pathway is associated with the angiogenesis grade and disease outcome for various solid tumors, including lung cancer [6, 7]. High VEGF-A in tumor tissue or in serum have proved to be related to advanced tumor stage and prognosis of non-small cell lung cancer [8,9,10].

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