The present/null polymorphism in the GSTT1 gene and the risk of lung cancer in Chinese population

Abstract

The present/null polymorphism in the GSTT1 gene has been implicated in susceptibility to lung cancer in Chinese population. A large number of studies have reported inconclusive results. The aim of the current study was to investigate the relationship between the present/null polymorphism in the GSTT1 gene and lung cancer risk in Chinese population by meta-analysis. The Pubmed, Embase, CNKI, and Wanfang databases were searched. The statistical analysis was performed by using Revman4.2 and Stata10.0. In summary, a total of 2,211 lung cancer cases and 3,115 controls in 18 case-control studies were included for data analysis. The results suggested that the null genotype carriers may contribute to increased risk of lung cancer in Chinese population when compared with the present genotype carriers (odds ratio = 1.24, 95% confidence interval = 1.02-1.49). The current meta-analysis suggested that the present/null polymorphism in the GSTT1 gene might contribute to the risk of lung cancer in Chinese population. Future studies are needed to validate these results.