CORRELATION OF ECHOCARDIOGRAPHIC INDICATORS AND CLINICAL-LABORATORY PARAMETERS TAKING INTO ACCOUNT THE AGT GENE (RS4762) IN PATIENTS WITH ARTERIAL HYPERTENSION

Abstract

The аim of the research – to assess the relationship between echocardiographic indices and clinical- laboratory parameters, taking into account genetic markers AGT (rs4762) in patients with essential arterial hypertension (EAH).
  
 Material and methods. The case-control study involved 100 patients with EAH stage II, 1-3 degrees of blood pressure (BP) increase, high and very high cardiovascular risk. Among the patients there were 21 % men, 79 % women. The middle age of the patients was 59.86±6.22y.o. The control group consisted of 60 practically healthy individuals, relevant in age (49.13±6.28y.o.) and gender distribution (63 % – women, 37 % – men). To study polymorphism of AGT (rs4762) and GNB3 (rs5443) genes a qualitative polymerase chain reaction (PCR) was performed in real time. The lipidogram indices were investigated in the blood plasma using diagnostic kits «Accent 200» firm (Poland). All patients were tested for levels of fasting glucose, ionized calcium, parathyroid hormone (PTH), 25-hydroxyvitamin D. The patients were performed echocardiography to determine the left ventricle hypertrophy. Results. The structural parameters of the myocardium, which determine the size of the LVH and the type of its geometric model, in patients with essential arterial hypertension (EAH) are influenced by the following indicators with a moderate strength of connection: concentric hypertrophy (CH LV) develops at a low level of high-density lipoprotein cholesterol (LPHD) (r= –0.59; р=0.008), ionized blood Ca2+ (r= –0.50; р=0.03) and increased PTH content (r=0.40; р=0.05) and high EchoCG indicators: increase in the size of the left atrium (LA), posterior wall thickness (PWT), interventricular septum in diastole (IVSd), left ventricle mass (LVM), left ventricular mass index (LVMI) and the relative left ventricular wall thickness (RWT) (r=0.47-0.65; p≤0.04-0.002). Conclusions. Structural and functional changes of the myocardium are correlated with a number of clinical, anthropometric, metabolic indicators and depend on polymorphic variants of the AGT gene (rs4762).