Abstract
Background: Hyperthyroidism is a thyroid disorder caused by increased synthesis and secretion of thyroid hormone by the thyroid gland. Hyperthyroidism is characterized by low thyroid stimulating hormone (TSH) and high free thyroxine (FT4) levels. The prevalence of hyperthyroidism in Indonesia was 0.6% in female and 0.2% in male. Zinc acts as an enzyme cofactor that converts thyroxine into triiodothyronine and it affects TSH synthesis. Adequacy of dietary zinc intake and serum zinc levels in hyperthyroid patients indirectly affects TSH and FT4 hormones.Objective: to analyze the correlation of dietary zinc intake and serum zinc with TSH and FT4 levels in adult hyperthyroid patients.Materials and Methods: This cross sectional study sampling based on inclusion and exclusion criteria which obtained 50 adult hyperthyroid patients at the Clinic of the Magelang Health Research and Development Center. Data of TSH and FT4 levels were measured by the ELISA method, serum zinc was measured with the ICP-MS method, dietary zinc intake’s data was collected using the 24 hour dietary recall and it was analyzed based on the table of Indonesian food composition 2017. Statistical analysis used in this study were spearman correlation and multivariate linear regression with 95% confidence level.Results : Dietary zinc intake did not correlate with both TSH and FT4 levels (p>0.05). Serum zinc had no correlation with TSH level (p>0.05), while serum zinc had a positive correlation with FT4 level (r=0.327; β=0.054; p<0.05).Conclusion: Serum zinc concentrations in adult hyperthyroid patients must be maintained because abnormal zinc status in the body’s metabolism will affect FT4 level.International Journal of Human and Health Sciences Vol. 05 No. 03 July’21 Page: 341-346
Highlights
Hyperthyroidism is collection of clinical symptoms caused by excess thyroid hormones.[1]
The most common cause of hyperthyroidism is Grave’s disease, an autoimmune disorder characterized by TSI stimulate thyroid gland to increase thyroid hormones secretion
Baseline Health Research of Indonesia in 2007 found 12.8% male and 14.7% female with low thyroid stimulating hormone (TSH) levels,[4] while based on the result of National Baseline Health Research 2013 there were 706,757 Indonesians aged ≥15 years who diagnosed with hyperthyroidism (0.4%)
Summary
Hyperthyroidism is collection of clinical symptoms caused by excess thyroid hormones.[1]. Baseline Health Research of Indonesia in 2007 found 12.8% male and 14.7% female with low TSH levels,[4] while based on the result of National Baseline Health Research 2013 there were 706,757 Indonesians aged ≥15 years who diagnosed with hyperthyroidism (0.4%). Central Java Province had 0.5% of hyperthyroid population, higher than the national prevalence of Indonesia.[6]. Study by Prasetyo et al (2018) showed that 74,3% of Indonesian adult population tends to have low zinc intake.[11]. Study in Pakistan showed that the mean level of serum zinc on hyperthyroid patients was lower than healthy subjects.[12]. Adequate zinc intake and serum zinc levels in hyperthyroid patients indirectly affect thyroid hormones. This study aimed to analyze the correlation between dietary zinc intake and serum zinc with TSH and FT4 levels in adult hyperthyroid patients
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