Correlation of Depth of Invasion and P53 Immunoexpression in Microinvasive Oral Squamous Cell Carcinoma

Abstract

Abstract Background: Oral squamous cell carcinoma (OSCC) is a major health problem and considered as the main reason for the mortality from oral diseases in most of the countries. One aspect of the OSCC was least discus in the literature that is microinvasive squamous cell carcinoma which is an early-stage tumor without invasion of deep tissues. this study is humble attempt to recognized and measured depth of invasion of infiltrative neoplastic cells to categories microinvasive oral squamous cell carcinoma (MIOSCC) and find suitable treatment plan for it Aim and objectives: To evaluate the depth of invasion and p53 immunoexpression in MIOSCC. To correlate the depth of invasion with p53 immunoexpression in MIOSCC. Material and Methods: The study included histopathologically diagnosed 25 cases of MIOSCC from the archives of the Department of Oral Pathology and Microbiology. Result: The depth of invasion was measured from the basement membrane or in areas of basement membrane loss and from an imaginary line reconstructing the basement membrane from the adjoining epithelium to the deepest point of invasion in connective tissue on research microscope. The p53 expression in the tissue section was seen through immunohistochemistry. Conclusion: There are no definite guidelines for histological grading and final treatment protocol for MIOSCC. The assessments of depth of invasion through p53 immunoexpression may be one of the criteria for grading in MIOSCC. Thus the correlation of p53 immunoexpression with the depth of tumor in MIOSCC helps to determine the treatment modalities of MIOSCC.