CORRELATION OF CLINICAL SYMPTOMS AND COMPUTER TOMOGRAPHY SCAN FINDINGS WITH HISTOPATHOLOGY IN PATIENTS WITH CHRONIC RHINOSINUSITIS

Abstract

Objectives: To determine the correlation between clinical symptoms, computer tomography scan (CT-scan), and histopathologic findings of chronic rhinosinusitis (CRS). Methods: A prospective, case-by-case study on 33 patients with CRS who were diagnosed and treated by functional endoscopic sinus surgery at the Department of Otolaryngology, Military Hospital 103 from January 2022 to August 2022. Results: There was an inverse correlation between sex and the number of Eosinophil cells/HPF cells, with p < 0.05; a moderate correlation between the SNOT-20 score and HPF cells (r = 0.4) and the degree of inflammation (r = 0.39), with p < 0.05; a moderate correlation between sneezing symptoms and smell disorders with HPF cells, r = 0.33 and r = 0.39 (p < 0.05); a low or moderate correlation between other functional symptoms and histopathological indicators (p < 0.05); a moderate correlation between the Lund-Kennedy score and the inflammation of the mucosa with r = 0.47, p < 0.05; a correlation between the degree of nasal polyps and histological indicators, but not statistically significant p > 0.05; a correlation between the average level of Lund-Mackay score and the degree of inflammation (r = 0.35), p < 0.05. Lund-Mackay score is positively correlated with HPF cells and negatively correlated with epithelial layer thickness, but not statistically significant p < 0.05. Conclusion: Mucosal eosinophilia moderately correlates with signs, but there was no correlation with the Lund-Kennedy score or Lund-Mackay score. Levels of inflammation are moderately correlated with objective disease severity as clinical symptoms, Lund-Kennedy score, and Lund-Mackay score.