Correlation of baseline clinical characteristics and laparoscopic extent of carcinomatosis of women with initially unresectable ovarian, tubal or peritoneal adenocarcinoma, in ANTHALYA study: A randomized, open-label, phase II study assessing the efficacy and the safety of bevacizumab in neoadjuvant.

Abstract

5538 Background: ANTHALYA study is a randomized non comparative clinical trial to evaluate the efficacy and safety of neoadjuvant chemotherapy associated with bevacizumab. It was a 2:1 randomization to receive carboplatin, paclitaxel with (experimental arm) or without (control arm) bevacizumab in the neoadjuvant setting. The extent of initial carcinomatosis is a major determinant of complete resection but is rarely well described. We report here the extent of carcinomatosis explored by laparoscopy of patients included in Anthalya and its correlation with baseline characteristics. Methods: Non-optimally resectable stage IIIC or IV ovarian cancer patients were eligible for this study. Disease extent was evaluated by a standardized form and the Fagotti score was calculated. Baseline clinical characteristics were compared to trials comparing primary debulking surgery and IDS. Results: This multicenter study was conducted in 15 centers: 205 patients have been screened and 95 patients were included. Median age ...