Correlation between the levels of tunlor type M2 pyruvate kinase with treatment response and prognosis in patients with non-small cell lung cancer

Abstract

Objective To study the expression of tumor type M2 pyruvate kinase(tumor M2-PK) in nonsmall cell lung cancer (NSCLC) and their correlation with treatment response and prognosis.Methods The concentration of tumor M2-PK in plasma was detected by ELISA in 106 healthy controls and 83 NSCLC patients.The patients were followed for 24 months.Results The patients after surgical operation showed marked reduction in plasma tumor M2-PK level(13.5 U/ml vs 25.4 U/ml,P<O.05).In the 15 patients with tumor remission the tumor M2-PK level(11.5 U/ml) was significantly lower than that(22.6 U/ml) before treatment(P<0.05).In the 20 patients with progressive disease the tumor M2-PK level(60.8 U/ml) was significantly higher than that(23.7 U/ml) of pretreatment(P<0.05).The tumor M2-PK concentration did not differ signigicantly before and after treatment in 17 patients with stable disease.The positive rates of tumor M2-PK decreased significantly after operation,but there was no significant change after chemotherapy.In the follow-up,the rate of relapse and metastasis was higher in patients Conclusions Plasma tumor M2-PK might be a useful marker in the detection of tumor mierometastases in NSCLC,and in evaluating treatment response and prognosis. Key words: Non-small cell lung cancer; Pyruvate kinase; Tumor marker