Correlation between the brain injury in patients with toxic encephalopathy and neuron specific enolase, serum glial fibers acidic protein and excitatory amino acids

Abstract

Objective To investigate the correlation between the brain injury in patients with toxic encephalopathy and neuron specific enolase (NSE), serum glial fibers acidic protein(GFAP) and excitatory amino acids(EAA). Methods From December 2013 to December 2014, 70 cases of toxic encephalopathy(toxic encephalopathy group) and 30 patients without nervous system disease (control group) were selected as the research objects. The serum levels of NSE, GFAP, and EAA of the two groups were compared. Results The serum levels of NSE, GFAP, and EAA of the toxic encephalopathy group patients were higher than those of the control group, those indexes in severe patient were most obvious(P<0.05). The brain injury in patients with toxic encephalopathy was positively correlated with NSE, GFAP and EAA(r=0.042, 0.038, 0.030, P<0.05). Conclusions The serum levels of NSE and GFAP and EAA are correlated with the brain injury degree in patients with toxic encephalopathy, the heavier of the degree of brain injury, the higher of the serum NSE, GFAP and EAA contents. Key words: Neuron specific enolization enzyme; Serum glial fibers acidic protein; Excitatory amino acids; Toxic encephalopathy