Application value of serum neuron specific enolase levels detection on evaluating the brain function abnormality in patients with acute exacerbation of chronic obstructive pulmonary disease combined with pulmonary encephalopathy

Abstract

Objective To investigate the application value of serum neuron specific enolase （ NSE）levels detection on evaluating the brain function abnormality in patients with acute exacerbation of chronic obstructive pulmonary disease（ AECOPD）combined with pulmonary encephalopathy. Methods One hundred and thirty-seven patients with COPD were divided into AECOPD group（ group A,36 cases） and COPD group（group B,101 cases）,50 healthy people were chose in control group（group C）. All the cases in the three groups received NSE level detection and electrocardiogram（ EEG）examination, NSE level and electrocardiogram of the three groups were analyzed. One hundred and thirty-seven patients with COPD were divided into≤15μg/L group and ﹥15 μg/L group according to NSE normal level（≤15 μg/L）,the abnormal rates of EEG of the two groups were compared. Results The abnormal rate of EEG and serum NSE level of group A was higher than that of group B and C significantly（ P﹤0. 05 ）,serum NSE level was not different between group B and C（ P﹥0. 05 ）. The abnormal rate of EEG in NSE≤15 μg/L group was lower than that in NSE ﹥15 μg/L group significantly（χ^2 =94. 97 ,P ﹤0. 01）. Conclusions Serum NSE level of AECOPD patients is higher than that of COPD patients and healthy people,the level is related to the abnormal rate of EEG,and can be used to evaluate the brain function abnormality in patients with AECOPD combined with pulmonary encephalopathy. Key words: Serum neuron specific enolase; Acute exacerbation of chronic obstructive pulmonary disease; Pulmonary encephalopathy; Brain function