Abstract
Increased oscillatory beta activity in basal ganglia is one of the main electrophysiological biomarkers of impaired motor control in Parkinson’s disease. However, the functional role of dynamical rhythmic processes during movements is still not investigated in detail. We used microelectrode recordings to investigate the subthalamic nucleus neuronal activity in 9 patients with Parkinson’s disease during deep brain stimulation surgery. We have shown that the amplitude of the subthalamic nucleus alpha (7–12 Hz) and low-beta (12–20 Hz) activity correlated with motor impairment indices in patients with Parkinson’s disease. Also, we have shown that, in contrast to beta rhythmic activity, the magnitude of alpha activity decreased significantly during motor tests execution. Moreover, the degree of rhythmic activity suppression in the alpha band correlated with the severity of bradykinesia. These results allow us to suppose that, along with beta activities, subthalamic nucleus neuronal alpha activity also participate in motor control of Parkinson’s disease patients.
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