Abstract
ObjectiveTo correlate serum level of monocyte chemoattractant protein-1 (MCP-1) with postoperative recurrence of spinal tuberculosis in the Chinese Han population.MethodsPatients of Han nationality with newly diagnosed spinal tuberculosis were consecutively included in this study. At different time points postoperatively, serum level of MCP-1 was determined using an enzyme linked immunosorbent assay. Recurrence of spinal tuberculosis after surgery and during the follow-up period was recorded. The correlation between serum MCP-1 level and recurrence of spinal tuberculosis was analyzed.ResultsA total of 169 patients with spinal tuberculosis were included in the study and followed up for an average of2.2±1.3 years (range, 1–5 years). Of these patients, 11 had postoperative recurrence of spinal tuberculosis. The patients’ serum level of MCP-1 increased significantly after postoperative recurrence of spinal tuberculosis. Once the symptoms of recurrence were cured, the serum level of MCP-1 decreased significantly and it did not differ from patients without disease recurrence.ConclusionPostoperative recurrence of spinal tuberculosis is likely to increase the serum level of MCP-1.
Highlights
Spinal tuberculosis is the most common form of skeletal system tuberculosis infection and it has a very high prevalence and morbidity in China [1]
Once the symptoms of recurrence were cured, the serum level of monocyte chemoattractant protein-1 (MCP-1) decreased significantly and it did not differ from patients without disease recurrence
In patients with spinal tuberculosis, the originally closed vomica will be opened after surgery, which unavoidably results in M. tuberculosis entering into the circulation and triggering a systemic immune response
Summary
Spinal tuberculosis is the most common form of skeletal system tuberculosis infection and it has a very high prevalence and morbidity in China [1]. As various anti-tuberculosis drugs poorly permeate foci and cold abscess in the vertebral body and do not always achieve effective therapeutic levels [2], it is difficult to treat spinal tuberculosis using drugs [3]. The tuberculosis foci on which anti-tuberculosis medications are not effective, such as caseous necrotic tissue, abscess and dead bone, can be removed, but the Mycobacterium tuberculosis bacilli cannot be completely cleared. Neither medication nor surgery is completely effective in removing spinal tuberculosis foci in vivo. The immunity of the host after spinal tuberculosis surgery has a decisive influence on the patient’s clinical prognosis [4,5,6]
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