Correlation between serum bisphenol A and testosterone levels in women with polycystic ovary syndrome

Abstract

The aim was to estimate the levels serum bisphenol A and testosterone levels in women with polycystic ovary syndrome. This prospective case-control study was done from January to June 2021 and included 40 women PCOS (17-38 years), fulfilling the Rotterdam PCOS diagnostic criteria. Among women, 31 patients belonged to the PCOS group. Women with diabetes mellitus, Cushing’s syndrome, infectious diseases, hypertension, thyroid dysfunction, hyperprolactinemia, oral contraceptives, antiandrogens, and infertility treatment during the period in the last 6 months. Presence of hirsutism and/or acne was taken as basis of patients Hirsutism scores were determined using the Modified Ferriman Gallwey scoring system. The diagnosis of PCOS is in accordance with the Rotterdam 2003 Criteria, such as oligomenorrhea. Serum bisphenol A and testosterone levels were measured in all patients. The relationship between the variables was examined using the Pearson correlation method. The conformity of the variables to the normal distribution was investigated. Belonging to continuous variables; median, minimum and maximum values are presented. If the P value was less than 0.05, the difference between the groups was considered statistically significant. The study showed that bisphenol A level was elevated significantly (P<0.01) in PCOS women (45.3 ± 9.24 ng/dl) as compared with control group, The study showed that testosterone level was elevated significantly (P<0.01) in PCOS women (0.18 ± 0.03 ng/dl) as compared with control group (1.53 ± 0.29 ng/ml). The study showed that the highest mean of prolactin was in PCOS women (25.86 ± 7.31 ng/dl) as compared with control group (18.11 ± 3.14 ng/dl), with highly significant difference (P<0.01).