Abstract

Objective To observe the changes of plasma levels of tissue-type plasminogen activator and inhibitor-1,and its relationship with kidney damage in children with Henoch-Schonlein Purpura.Methods Plasma levels of tissue-type plasminogen activator ( t-PA) and plasminogen activator inhibitor-l( PAI-1) were measured by enzyme-linked immunosorhent assay.Results Plasma levels of t-PA and PAI-1 in children with Henoch-Schonlein Purpura with kidney damage( group A) were significantly higher than those of the controls in acute phase and recovery phase (P ＜ 0.01).The levels of t-PA/PAI-I in group A were significantly lower than those of the controls in acute phase and recovery phase (P ＜ 0.01) ; Plasma levels of t-PA and PAI-1 in children with Henoch-Schonlein Purpura without kidney damage( group B) were significantly higher than those of the controls in acute phase ( P ＜ 0.01) and reduced to normal in recovery phase.The levels of t-PA/PAI-1 in group B were normal in acute phase and recovery phase; The levels of t-PA in group A were significantly lower in acute phase and significantly higher in recovery phase than those in group B ( P ＜ 0.01).The levels of PAI-I in group A were significantly higher than those in group B in acute phase and recovery phase (P ＜ 0.01).The levels of t-PA/PAI-1 in group A were significantly lower than those in group B in acute phase and recovery phase (P ＜ 0.001).Conclusions Impairment of the fibrinolytic system maybe related to the kidney damage in children with Henoch-Schonlein Purpura. Key words: Child; Henoch-Schonlein purpura; Nephritis; Tissue-type plasminogen activator; Plasminogen activator inhibitor-1

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