Correlation between parity and metabolic syndrome in Chinese women aged 40\u2009years and older: the Reaction study

Qian Xie,Haoran Xu,Qin Wan

doi:10.1186/s12902-021-00902-7

Abstract

AimsThe purpose of the present study was to investigate the correlation between the number of live-birth pregnancies and metabolic syndrome (MetS) in Chinese women according to menstruation history.MethodsRegistry data for all pregnancies in a cohort of 6157 Chinese women aged 40 years or older were obtained and the number of live-birth pregnancies were enumerated. We defined MetS using five criteria: impaired insulin metabolism and glucose tolerance, obesity in the abdominal area, dyslipidemia, and hypertension. Multivariate logistic regression analysis was conducted to assess potential risk factors for MetS. Postmenopausal women with three or more of live-birth pregnancies had the highest prevalence of MetS (P < 0.05).ResultsAmong the 6157 females aged 40 years or older in Luzhou city, 2143 (34.8%) participants had incident MetS. The number of live-birth pregnancies was significantly correlated with age and fasting blood glucose (FBG) level (P < 0.05). The prevalence of MetS increased with the number of live-birth pregnancies (P < 0.01), and the frequency in postmenopausal women was significantly higher than that in premenopausal women (P < 0.001). In the binary logistic regression model, menopausal status [OR = 0.343 (0.153–0.769), P < 0.001] were significantly associated with an increased risk of MetS.ConclusionsThe number of live-birth pregnancies is correlated with an increased risk of MetS in Chinese women aged 40 years and over, especially in postmenopausal women. Greater attention should be paid to postmenopausal women who have had multiple live-birth pregnancies with a view to intervening early to prevent related diseases.

Highlights

Metabolic syndrome (MetS) is a multifaceted disease characterized by impaired insulin metabolism and glucose tolerance, obesity in the abdominal area, dyslipidemia, and hypertension [1]
The results indicate that the number of live-birth pregnancies (P < 0.01) and fasting blood glucose (FBG) (P < 0.01) increased with age
There was no significant difference in postprandial blood glucose (2hPG), HbA1c, TC, TG, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), waist circumference, hip circumference, or systolic blood pressure (SBP) between women with 3 live births and 4 live births

Summary

Introduction

Metabolic syndrome (MetS) is a multifaceted disease characterized by impaired insulin metabolism and glucose tolerance, obesity in the abdominal area, dyslipidemia, and hypertension [1]. Pregnancy leads to significant metabolic changes, such as increased production of insulin; reduced insulin sensitivity; and increased fat mass, triglycerides, low-density lipoprotein cholesterol, and blood glucose [17, 18]. These changes that occur during pregnancy are almost completely reversed following delivery, the lasting effects of the state of inflammation can result in an increased risk of hypertension and CVD in later life [19 20]. Knowledge is lacking regarding the correlation between MetS and the number of live-birth pregnancies in Chinese women aged 40 years and over; in the present study, we investigated this correlation, in addition to the association between menopause and MetS

Methods

Results

Discussion

Conclusion