Waist Circumference Coupled with Either HDL-C or TG Can Be Used as a Diagnostic Marker for Metabolic Syndrome in Chinese Women with Polycystic Ovary Syndrome.

Yan Sun,Qi Shen,Fei He,Wenchang Zhang,Shengrong Du,Yiwei Guo,Wenxiang Wang

doi:10.1155/2018/6102085

Yan Sun, Qi Shen + Show 5 more

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https://doi.org/10.1155/2018/6102085

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Abstract

Although quite a few polycystic ovary syndrome (PCOS) patients suffering from metabolic syndrome (MS) have been reported in previous studies, no reliable and early diagnostic biomarkers for MS in PCOS patients have yet been identified. To identify early and reliable diagnostic biomarkers for MS in Chinese women with PCOS, a total of 401 patients (200 PCOS patients and 201 controls) were enrolled in our present study. All of the subjects were examined for anthropometric (weight, waist circumference, blood pressure, etc.) and biochemical (fasting glucose, serum lipid indices, total testosterone, etc.) parameters. Our results showed that the prevalence of MS in the PCOS patients (20.50%) was 6.8-fold higher (P < 0.05) than that in the controls (2.99%). Nearly 71.0% of the PCOS patients had at least one component of MS, of which dyslipidemia was the most prevalent. Furthermore, within the PCOS group, the prevalence of MS increased with increasing age and body mass index (BMI). Logistic analysis indicated that BMI, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), hypertension, and fasting glucose were significantly associated with the presence of MS in PCOS patients. Analysis of the ability of the potential diagnostic biomarkers to indicate MS in PCOS patients showed that the PPV, NPV, specificity, sensitivity, and Youden's index for waist circumference (WC) coupled with HDL-C were 59.68%, 97.10%, 84.28%, 90.24%, and 74.52, respectively, and those for WC coupled with TG were 93.33%, 92.35%, 98.74%, 68.29%, and 67.03%, respectively. ROC curve analysis showed that the areas under the ROC curves (AUCs) for WC coupled with HDL-C and for WC coupled with TG were 0.882 and 0.901, respectively. Our present study demonstrates that WC coupled with either HDL-C or TG can be used as a relatively early and reliable diagnostic biomarker for MS in Chinese PCOS patients.

Highlights

Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disease with an incidence of 5–10% in premenopausal women and is one of the common endocrine causes of infertility in women of childbearing age [1,2,3]
The bold values represent differences that were considered statistically significant at P < 0 05
The results showed that the areas under the Receiver operating characteristic (ROC) curves (AUCs) for waist circumference (WC) coupled with high-density lipoprotein cholesterol (HDL-C) and for WC coupled with TG were 0.882

Summary

Introduction

Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disease with an incidence of 5–10% in premenopausal women and is one of the common endocrine causes of infertility in women of childbearing age [1,2,3]. Women with PCOS have a higher risk of gynecological cancers [4,5,6]. Previous studies have demonstrated that PCOS is associated with multiple metabolic abnormalities, including obesity, dyslipidemia, and impaired glucose tolerance, which are components of the metabolic syndrome (MS) [7]. PCOS increasingly affects both the reproductive system and metabolic system in relation to MS [8]. The metabolic syndrome can severely affect health; its manifestations include obesity, hyperinsulinemia, insulin resistance (IR), abnormal lipid metabolism, high blood pressure, and many other metabolic diseases [9, 10]. PCOS is considered a risk factor for type 2 diabetes mellitus and cerebrovascular disease, suggesting the importance of identifying early biomarkers for MS in PCOS patients

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