Abstract
BackgroundMatrix metalloproteinase 2 (MMP2) has been found to be related to malignant tumors; the aim of this study was to investigate the correlation between MMP2 expression in lung cancer tissues and clinical parameters of lung cancer.MethodsThe expression of MMP2 in lung cancer tissues and in adjacent non-malignant tissues was tested by immunohistochemistry. The correlation between the expression of MMP2 and clinical parameters of lung cancer was analyzed by Kaplan-Meier curve and multiple regression analysis.ResultsThe expression of MMP2 was higher in lung cancer tissues than that in adjacent non-malignant tissues (p = 0.002). Increased MMP2 was associated with low differentiation (p = 0.022), tumor size (p = 0.032), lymph node metastasis (p < 0.001), advanced stage (p = 0.002). The post-surgical survival time in patients with high MMP2 expression was shorter than that in patients with low MMP2 expression (p = 0.001). High expression of MMP2 (p = 0.006) and advanced stage (p = 0.003) were independent prognostic indicators for survival of lung cancer patients.ConclusionsIncreased MMP2 correlates with malignant biological behavior of lung cancer and it could be a potential biomarker for diagnosis and prognosis of the disease.
Highlights
Lung cancer is divided into non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) in clinical practice [1]
Expression of Matrix metalloproteinase 2 (MMP2) in lung cancer tissues was higher than that in adjacent normal tissues In IHC analysis, MMP2 was mainly expressed in cytoplasm and membrane of lung cancer cells and normal cells (Fig. 1a-f)
Statistical analysis showed that high expression rate of MMP2 reached 37% (24/65) in lung cancer tissues, whereas only accounted for 20% (13/65) in the adjacent non-malignant tissues, which suggested that the expression of MMP2 in lung cancer tissues was higher than that in adjacent normal tissues (p = 0.002) (Table 2, Fig. 2a)
Summary
Lung cancer is divided into non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) in clinical practice [1]. Most lung cancers are NSCLC, which is significantly different from SCLC in pathology, pathogenesis and prognosis [2]. It has been confirmed that many molecular signals are involved in the occurrence and development of lung cancer, which are often related to the abnormal expressions of some proteins. Matrix metalloproteinase 2 (MMP2) is one of the members of MMPs. The gene sequence encoding MMP2 contains 13 exons and 12 introns [8]. Matrix metalloproteinase 2 (MMP2) has been found to be related to malignant tumors; the aim of this study was to investigate the correlation between MMP2 expression in lung cancer tissues and clinical parameters of lung cancer
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