Abstract
Objective To investigate the relationship between microalbuminuria (MAU) and short-term outcome in patients with acute ischemic stroke. Methods The consecutive patients with acute ischemic stroke admitted to hospital were enrolled prospectively. The first urine specimen was taken on the following morning after admission for detecting urine albumin/creatinine ratio (UACR). UACR 30-300 mg/g was defined as MAU positive. Stroke severity was evaluated with the National Institutes of Health Stroke Scale (NIHSS) at admission and the modified Rankin Scale (mRS) was used to evaluate functional outcome at discharge, and good outcome was defined as mRS score of 0 to 2. Results A total of 244 patients with acute ischemic stroke were enrolled, including MAU positive in 53 patients (27.12%), and poor outcome in 67 patients (27.50%). Univariate analysis showed that age, baseline NIHSS score, systolic blood pressure, fasting blood glucose, globulin, D-dimer, white blood cell count, neutrophils, and the proportions of ischemic heart disease in patients of the MAU positive group were significantly higher than those of the MAU negative group (all P<0.05). Multivariate logistic regression analysis showed that MAU (odds ratio [OR] 1.520, 95% confidence interval [CI] 1.151-1.794; P=0.031), baseline NIHSS score (OR 1.570, 95% CI 1.357-1.808; P<0.001) were the independent risk factors for short-term poor outcome in patients with acute ischemic stroke. Conclusions The incidence of MAU is high in patients with acute ischemic stroke. MAU positive can be used as one of the independent predictors of short-term poor outcome in patients with acute ischemic stroke. Key words: Stroke; Brain Ischemia; Albuminuria; Prognosis; Biomarkers; Risk Factors
Published Version
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