Correlation between matrix metalloproteinases and brain natriuretic peptide in patients with chronic heart failure

Abstract

Objective To investigate the changes in serum matrix metalloproteinase(MMP)-2 and MMP-9 and their relationship with serum B-type brain natriuretic peptide(BNP)in patients with chronic heart failure. Methods MMP-2, MMP-9 and serum BNP levels were measured in 184 patients with chronic heart failure and 61 healthy controls.The relationship between changes in MMP-2 and -9 and serum BNP was analyzed. Results Chronic heart failure was categorized into grade Ⅱ, Ⅲ and Ⅳ according to NYHA.In grade Ⅱ, Ⅲ and Ⅳ and the control group, the levels of MMP-2 were(309.1±60.1)nmol/L, (422.6±89.6)nmol/L, (694.8±126.2)nmol/L and(217.2±26.3)nmol/L respectively, and the levels of MMP-9 were (321.2±63.2)nmol/L, (454.4±96.3)nmol/L, (634.1±51.2)nmol/L and(210.8±23.6)nmol/L respectively.The levels of MMP-2 and MMP-9 were significantly higher in chronic heart failure subgroups than in the control group(F=3.65, 12.52; P=0.000, 0.000). According to the pairwise comparison among the chronic heart failure subgroups, the levels of serum MMP-2 and MMP-9 were significantly higher in NYHA Ⅳ grade than in NYHA Ⅲ grade, and higher in NYHA Ⅲ grade than in NYHA Ⅱ grade(all P<0.05). In patients with chronic heart failure groups, MMP-2 was positively correlated with serum BNP(r=0.866, P=0.000), and with MMP-9(r=0.516, P=0.001). Conclusions MMP-2 and MMP-9 levels might be closely correlated with chronic heart failure and show an upward trend with the progression of chronic heart failure.The levels of MMP-2 and MMP-9 are associated with BNP, which indicates that clinical monitoring of the serum level changes can provide a certain reference for diagnosis, treatment and prognosis in patients with chronic heart failure. Key words: Heart failure; Matrix metalloproteinases; Natriuretic peptide, brain