Abstract
In Pakistan, there is limited evidence for the levels and relationship of 25 (OH) Vitamin D (25(OH)D) status in pregnant women and their newborns, while the association between maternal 25(OH)D and newborn anthropometric measurements remains unexplored. Sociodemographic data were collected from 213 pregnant mothers during their visit to a tertiary care hospital at the time of childbirth. Anthropometric measurements were performed on all mothers and their newborns and blood samples collected from both for 25(OH)D levels. Participants were classified into two groups according to their 25(OH)D status: sufficient (25(OH)D ≥50 nmol L−1) and deficient (25(OH)D <50 nmol L−1). Simple and multiple regression models were used for analysis. Among 213 pregnant women, prevalence of 25(OH)D deficiency was 61.5%, and their newborn was 99.5% (mean 25(OH)D levels: 46.3 [11.3] and 24.9 [5.4] nmol L−1, respectively). Maternal sociodemographic characteristics were similar between 25(OH)D deficient and sufficient mothers, whereas newborn 25(OH)D levels were significantly lower in the former (22.60 [4.53] vs. 27.67 [3.82] nmol L−1, respectively, P < 0.001). There was a strong positive association between maternal and newborn 25(OH)D levels (r, 0.66; r 2, 43%, B [SE], 0.3 [0.02]; P < 0.001). Association of maternal 25(OH)D levels with newborn weight, length and head circumference was not significant (all P > 0.05). Our study shows a high prevalence of 25(OH)D deficiency in pregnant women and their newborns and a strong positive association between maternal and newborn 25(OH)D levels. Findings of this study indicate the importance of maintaining sufficient 25(OH)D levels during pregnancy.
Highlights
25 (OH) Vitamin D (25(OH)D), a fat soluble secosteroid (Veena et al, 2016), contributes towards numerous physiological (Carlberg, 2014) and metabolic (Bikle, 2014) processes in human body
Our study shows a high prevalence of 25(OH)D deficiency in mothers of newborn infants, women (61.4%) and their newborns (99.5%)
A meta-analysis of observational study revealed that newborns of mothers with 25(OH)D levels of
Summary
25 (OH) Vitamin D (25(OH)D), a fat soluble secosteroid (Veena et al, 2016), contributes towards numerous physiological (Carlberg, 2014) and metabolic (Bikle, 2014) processes in human body. Role of 25(OH)D in pregnant women and the newborn has been well established (Bowyer et al, 2009). The effects of Vitamin D deficiency in pregnant women include backache/leg cramps Evidence regarding the strength of relationship between maternal and newborns 25(OH)D levels, from Pakistan, shows marked variation (Hossain et al, 2011; Karim, Nusrat, & Aziz, 2011; Khan, Iqbal, Naureen, Dar, & Ahmed, 2012; Riaz et al, 2016), while the association between maternal 25(OH)D levels and anthropometric measurements of the newborn remains unexplored. This study aims to measure 25(OH)D status among pregnant women and their newborns and explore the relationship between maternal 25(OH)D levels and the 25(OH)D levels and anthropometric measurements (weight, length and head circumference) of the newborn. We conducted a cross-sectional study on healthy pregnant women and their newborns, who visited the Department of Obstetrics and Gynaecology, Military Hospital Rawalpindi from 1 September 2015 to 28 February 2016. Antenatal visits should include education on the safety and importance of Vitamin D supplementation and sufficient sunlight exposure during pregnancy
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
