Correlation between mammograghic findings and clinical/ pathologic features in women with small invasive breast carcinomas.

Jun-Nan Li,Pei-Fang Liu,Jing Xu,Chun Qing,Ju Wang,Yu-Mei Zhao

doi:10.7314/apjcp.2014.15.24.10643

Jun-Nan Li, Pei-Fang Liu + Show 4 more

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https://doi.org/10.7314/apjcp.2014.15.24.10643

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To study the relationship between mammographic findings and clinical/pathologic features in women with 1-15mm sized invasive breast cancer. We investigated a consecutive series of 134 cases diagnosed in Tianjin Medical University Cancer Institute and Hospital in 2007. Mammographic findings were classified into five groups as follows :1) stellate mass without calcification; 2) non-stellate mass without calcification; 3) intermediate suspicious calcification with or without associated mass; 4) higher probability malignant calcification with or without associated mass; 5) focal asymmetry/distortion without associated calcification. Associations between mammographic and clinical/pathological features (menopause status/family history/histologic grade/lymph node status and ER/PR/HER2 status) was analyzed through logistic regression and chi square tests. Compared to the stellate mass without calcification group, higher probability malignant calcification patients were associated significantly with a positive lymph node status, always presenting in patients who were non-menopausal and with a family history of carcinoma. Higher probability malignant calcifications with or without associated tumor masses are associated with clinical/pathologic features of poor prognosis.

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Breast cancer is a major public health challenge, and the survival of breast cancer patients is improved by decreasing of tumor size
We tried to find the relevence between mammography and clinical/pathologic features, in order to provide some information for the prognosis of small breast cancer
According to Breast Imaging Reporting and Data System (BI-RADS), the mammographic appearance of the tumors in the current study was classified into five groups that was similar to Tabar et al (2000; 2004): 1) stellate mass without calcifications; 2) non-stellate mass without calcifications; 3) intermediate suspicious calcifications with or without associated mass; 4) higher probability malignant calcifications with or without associated mass; 5) focal asymmetry/distortion without associated calcifications

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Introduction

Breast cancer is a major public health challenge, and the survival of breast cancer patients is improved by decreasing of tumor size. Some research published after that showed conflictive results (Thurfjell et al, 2001; James et al, 2003; Peacock et al, 2004; Evans et al, 2006) In this retrospective study, we tried to find the relevence between mammography and clinical/pathologic features, in order to provide some information for the prognosis of small breast cancer. To study the relationship between mammographic findings and clinical/pathologic features in women with 1-15mm sized invasive breast cancer. Results: Compared to the stellate mass without calcification group, higher probability malignant calcification patients were associated significantly with a positive lymph node status, always presenting in patients who were non-menopausal and with a family history of carcinoma. Conclusions: Higher probability malignant calcifications with or without associated tumor masses are associated with clinical/pathologic features of poor prognosis

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