Correlation between levels of adipokines and inflammatory mediators with spirometric parameters in individuals with obesity and symptoms of asthma: Cross-sectional study

Abstract

IntroductionThe adipose tissue secretes adipokines and influences the release of inflammatory mediators contributing to a state of low-grade systemic inflammation that may change lung function. ObjectiveTo correlate levels of adipokines and inflammatory mediators with lung function in individuals with obesity and bronchial asthma symptoms. Materials and methodsA cross-sectional study, including women with obesity (grade II and III) with symptoms and clinical diagnosis of asthma. Anthropometric measurements (weight, height, BMI), pulmonary function test (spirometry), asthma control test questionnaire, collection of systemic inflammatory markers (blood collection) and pulmonary markers (sputum collection) were collected and were analyzed: IL-6, IL-8, TNF-α, adiponectin, resistin, leptin and C-reactive protein (CRP). The patients were stratified into two groups according to asthma control. Results80 women were analyzed and 40% had an ACT score greater than or equal to 18 and were classified as “controlled asthma”. More than half of the patients of ACT<18 score obtaining measures of FEV1, PEF and FEF25–75% below and 80% of predicted. There was a significant and negative correlation between IL-6 in the sputum with FVC and FEF25–75% in the group ACT<18 and with FVC and FEV1 in the group ACT≥18. ConclusionsTherefore, we concluded that the increase of interleukin-6 in the sputum is related to worse pulmonary function even in patients with controlled asthma, especially in the translate airway permeability measures.