Abstract
The aim of this study was to analyze (i) ratios between pro-inflammatory cytokines interleukin 6 (IL-6), interleukin 1 (IL-1), tumour necrosis factor alpha (TNF-alpha) and anti-inflammatory cytokine interleukin 10 (IL-10) in patients with acute myocardial infarction (AMI) and stable angina pectoris (ii) as well as correlation between IL-6 and IL-10 in AMI and (iii) correlation between IL-6 and lipoproteins in AMI.The total of 71 patients were enrolled in this study, 41 of them with AMI (study group) and 30 with stable angina pectoris (control group). The concentrations of cytokines and lipoproteins were measured from blood samples. Pro-inflammatory to anti-inflammatory cytokine ratios were calculated by dividing concentrations of pro-inflammatory cytokines with IL-10. In statistical analyses we used descriptive statistics, normality tests and analysis of correlation.IL-6: IL-10 ratio is significantly higher in AMI than in stable angina (P < 0,001), TNF-alpha: IL-10 is also higher in study group but the difference is not significant. We found positive linear correlation between IL-6 and IL-10 (r =0,43; p = 0,015) and negative linear correlation between IL-6 and high density lipoprotein HDL (r = -0,47; p= 0,008) in AMI.IL-6: IL-10 ratio is higher in AMI than in stable angina. There is linear correlation between IL-6 and IL-10 and IL-6 and HDL in AMI.
Highlights
The role of anti-inflammatory cytokine IL- is still controversial
The aim of study was to determine the concentrations of pro-inflammatory cytokines IL, IL- β, tumour necrosis factor α (TNF-α) and hs-CRP, concentration of anti-inflammatory cytokine IL- and pro-inflammatory to anti-inflammatory cytokine ratios in group of patients with acute myocardial infarction (AMI) and to compare them with the values obtained in patients with stable angina pectoris
The study included patients with AMI and patients with stable angina pectoris who were treated in our institution over the period . . - . . . Myocardial infarction was diagnosed following the criteria: anamnesis of chest pain and/or ECG changes suggestive of infarction or ischemia with an increase in one or more cardiac enzymes levels to at least twice the upper limit of the normal range
Summary
The role of anti-inflammatory cytokine IL- is still controversial. The balance between pro-inflammatory and anti-inflammatory cytokines may reflect the intensity of occult plaque inflammation and the vulnerability to rupture ( ). Pro-in inflammatory to anti-inflammatory cytokine ratios can signal the balance between proinflammatory and anti-inflammatory forces ( ). The aim of study was to determine the concentrations of pro-inflammatory cytokines IL- , IL- β, TNF-α and hs-CRP, concentration of anti-inflammatory cytokine IL- and pro-inflammatory to anti-inflammatory cy-. Tokine ratios in group of patients with AMI and to compare them with the values obtained in patients with stable angina pectoris.
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