Abstract
Colorectal cancer (CRC) is classified as one of the most prevalent cancer types worldwide, with high morbidity and mortality rates. Patients of CRC have been shown to express a detectable cytokine in serum which contributes to cancer pathogenesis. Therefore, the serum interleukin 10 (IL-10) level in CRC patients was investigated in this study. Patients' medical records with CRC admitted to the Rizgary and Nanakali hospitals, Erbil, Iraq was analyzed as the study group compared to the healthy volunteers' control group. Seventy-one serum samples were collected, thirty-one from diagnosed CRC patients and forty from healthy controls. The concentrations of IL-10 in the sera were assessed by enzyme-linked immunosorbent assay (ELISA). The present finding showed that IL-10 Was significantly elevated in CRC patients' sera compared to the control group, suggesting confirmation of its usefulness for detecting CRC patients' prognosis. A non-significant Pearson correlation was detected between IL-10 serum levels and the CRC group's age, gender, and body mass index. Herein is the first study on the evaluation of IL-10 levels in CRC patients in Kurdistan, Iraq.
Highlights
Cancer is a worldwide health problem, mainly in developing countries
The results showed a significant increase in IL10 level in the Colorectal cancer (CRC) group compared to H.C. (p
The present findings reported a significant elevation in interleukin 10 (IL-10) level in the CRC group compared to H.C. (p
Summary
Cancer is a worldwide health problem, mainly in developing countries. GLOBOCAN recorded 18.1 million cancer cases, and 9.6 million deaths resulted from cancer in 2018. It is a significant reason for morbidity and mortality worldwide, regardless of the human development status [1]. Colorectal cancer (CRC) is categorized as the 3rd most frequently identified cancer type and the 4th reason for cancer deaths globally. Despite the progress in diagnostic and therapeutic methods, CRC remains a significant health problem with high morbidity and mortality [3]. CRC is predominant and responsible for about 10% of cancerrelated mortality in western countries. Its increase in developed countries can be related to aging people, unfavorable dietary habits, and increased risk influences such as smoking, little physical exercise, and obesity [4]
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