Abstract
ObjectiveThis meta-analysis was implemented to evaluate the association between hypoxia-inducible factor-1α (HIF-1α) C1772T/G1790A polymorphisms and susceptibility to head and neck cancer (HNC).Material and methodsThis meta-analysis has been registered on PROSPERO platform (CRD42021257309). The PubMed, Embase and Web of Science databases were searched to retrieve eligible published papers. STATA software was used to calculate the pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) to assess the correlation strength.ResultsOur results demonstrated that the HIF-1α C1772T polymorphism was significantly related to an increased HNC risk (OR = 2.27, 95% CI = 1.17–4.42 for the homozygous model; OR = 11.53, 95% CI = 1.11–120.4 for the recessive model), especially in Caucasians (OR = 2.16, 95% CI = 1.09–4.27 for the homozygous model; OR = 2.28, 95% CI = 1.15–5.51 for the recessive model). Similarly, a remarkable correlation was discovered between the G1790A polymorphism and HNC risk (OR = 72.11, 95% CI = 2.08–2502.4 for the homozygous model; OR = 58.05, 95% CI = 1.70–1985.77 for the recessive model). Moreover, in the subgroup analysis by source of controls, a statistically significant correlation was discovered in the population-based (PB) subgroup (OR = 9.43, 95% CI = 1.20–73.9 for allelic model; OR = 72.11, 95% CI = 2.08–2502.4 for the homozygous model; OR = 3.22, 95% CI = 1.28–8.08 for the heterozygous model; OR = 7.83, 95% CI = 1.48–41.37 for the dominant model; OR = 58.05, 95% CI = 1.70–1985.8 for the recessive model) but not in the hospital-based (HB) subgroup.ConclusionOur study found that both HIF-1α C1772T and G1790A polymorphisms might be a higher risk of HNC, especially in the Caucasian group with the C1772T polymorphism.
Highlights
Head and neck cancer (HNC), which includes oropharyngeal cancer, nasopharyngeal cancer, laryngeal cancer and tongue cancer, is the eighth most common cancer according to the latest data reported in the GlobalCancer Statistics 2018 [1, 2]
Our study found that both hypoxia-inducible factor-1α (HIF-1α) C1772T and G1790A polymorphisms might be a higher risk of HNC, especially in the Caucasian group with the C1772T polymorphism
Among the 7 enrolled studies, 7 studies were correlated with the C1772T polymorphism [32, 34, 36,37,38,39,40], and 6 studies were related to the G1790A polymorphism [30, 32, 37,38,39,40]
Summary
Cancer Statistics 2018 [1, 2]. More than 550,000 new cases of HNC occur worldwide each year, with 300,000 deaths [3]. The treatment of HNC patients is progressing, the age of patients has gradually decreased in recent years [4], which may be due to the infection of human papillomavirus (HPV), environmental pollution and unhealthy living habits [5, 6]. Infection of HPV can cause a variety of cancers, such as cervical cancer and oropharyngeal cancer, and has recently attracted the attention of scientists as another important risk factor for HNC [14, 15]. Not every individual exposed to the above conditions will have HNC, which indicates that individual genetic susceptibility is an important factor in the occurrence of HNC [6, 16, 17]
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