Abstract
To determine the association between hyperglycemia, glycated albumin (GlyA) and retinopathy of prematurity (ROP). Prospective study of all infants under ROP screening from March 2017 to July 2019. All demographic, clinical and laboratory data were collected. Glucose was measured at birth and every 8 h for the first week and serum GlyA was evaluated at birth, 1st, 2nd and 4th weeks after birth. Reference range for GlyA was obtained. Univariate logistic regression was used to examine risk factors for ROP followed by multivariate regression. A total of 152 infants were included in the study. Median gestational age was 30 weeks and median birth weight 1240 g. Thirty-three infants (21.7%) had ROP. Hyperglycemia was present in 24 (72.7%) infants diagnosed with any ROP versus 6 (0.05%) in those without ROP. Median GlyA at birth, 1st, 2nd and 4th and respective reference ranges were 8.50% (6.00–12.65), 8.20% (5.32–11.67), 8.00% (5.32–10.00) and 7.90% (5.30–9.00) respectively. After multivariate logistic regression, hyperglycemia but not GlyA, remained a significant risk factor for ROP overpowering the other recognized risk factors (Exp (B) 28.062, 95% CI for Exp(B) 7.881–99.924 p < 0.001). In our cohort, hyperglycemia but not GlyA, remained a significant risk factor for ROP overpowering the other recognized risk factors.
Highlights
We evaluated gestational age (GA), birth weight (BW), sex, small for GA status, gestational diabetes, hyperglycemia, exposure to insulin, GlyA, days before first discharge, hyaline membrane disease, bronchopulmonary dysplasia, need of oxygen > 28 days, days of mechanical ventilation, days of oxygen supplementation, thrombocytopenia (≤ 50,000 platelets per microliter), thrombocytosis (≥ 500 × 1 03/l), postnatal steroids, early red cell transfusion, total red cell transfusions, anemia (< g/ dl) during the first week after birth, persistent ductus arteriosus, peri and intraventricular hemorrhage, diuretics, days of phototherapy, early and late onset sepsis, necrotizing enterocolitis (NEC) and absence of maternal milk
Hyperglycemia was present in 24 (72.7%) infants diagnosed with Retinopathy of prematurity (ROP) versus 6 (5.0%) without ROP
Our aim was to determine the association between hyperglycemia, GlyA and ROP and further compare them with other known risk factors
Summary
The objective of this study was to determine the association between hyperglycemia, GlyA and ROP. Our aim was to determine the association between hyperglycemia, GlyA and ROP and further compare them with other known risk factors
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