Abstract
Objective To analyze the correlation between the concentration of hyaluronic acid in follicular fluid and oocyte retrieval results in the patients with diminished ovarian reserve. Methods The concentration of anti-Mullerian hormone (AMH) in serum, hyaluronic acid and progesterone in follicular fluid of 34 patients with none oocytes retrieved (study group) and 39 patients with successful retrieval (control group) were measured and compared. Results The concentration of AMH level [(0.55±0.37) μg/L] in serum and hyaluronic acid [(274±65) μg/L] in follicular fluid were lower than that in control group [(0.75±0.42) μg/L, P=0.033; (347±86) μg/L, P<0.001]. The level of progesterone in follicular fluid [(91.4±25.3)×103 nmol/L] was higher than that in control group [(81.3±15.6)×103 nmol/L, P=0.042]. Conclusion The failure of oocytes retrieval in diminished ovarian reserver is related to the insufficiency of hyaluronic acid in follicular fluid. Key words: Follicular fluid; Anti-Mullerian hormone (AMH); Hyaluronic acid; Ovarian reserve
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