Abstract
The aim of the study is to to determine correlation Hasford score and early molecular response in chronic phase BCR-ABL-Positive CML patients treated with imatinib. This is an longitudinal observational study in newly diagnosed patients of CML chronic phase BCR-ABL-Positive treated imatinib from Januari 2017 to September 2017. Patients were stratified according to Hasford score at diagnosis. Q-PCR(Quantitative RT-PCR) were used to monitor BCR-ABL transcription levels after 3 months of imatinib treatment. Correlation between Hasford score with early molecular response were analyzed using Koefisien Kontingensi’s correlation test. Results: Thirty five patients were enrolled in this study consist of 13 male and 22 female. After 3 months of imatinib treatment, EMR were 5 patients (83.3%), 11 patients (61.1%) and 2 patients (18.2%) in low, intermediate, and high risk group patients, respectively. Koefisien kontigensi test showed that there was significant correlation between Hasford score and EMR (p=0.018; r=0.431). The Hasford score correlated to early molecular response in chronic phase BCR-ABL-positive CML patients received imatinib.
Highlights
Jumal llmiah lntemational terindeks di Web of soence clarivate analytics / kelompok emerging sources citation indeks
Conelation between hasford score witr early molecular response in patients with chronic myeloid leukemia in chronic phase treated with imatinib
Corclation between hasford score with early molecular response in patients with chronic myeloid leukemia in chronic phase treated with imatinib
Summary
Telah diperiksa dan divalidasi dengan baik, dan sampai pemyataan ini dibuat sebagai karya ilmiah original. Fhgne$r sehingga kami turut bertanggung jawab bahwa karya ilmiah tersebut telah memenuhi syaral kaidah ilmiah, norma akademik, dan norma hukum, sesuai dengan Peraturan Menteri Pendidikan Nasional Nomo|17 Tahun 2010 tanggal 16 Agustus 2010 tentang Pencegahan dan Pananggulangan Plagiat di Perguruan Tinggi. Apabila di kemudian hari temyata tebukti bahwa karya ilmiah tersebut merupakan karya llmiah Plagiat, maka akan menjaditanggung jawab mutlak penulis. Demikian sural pemyataan ini saya buat untuk dip atas, baik secara perdata maupun pidana
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