Correlation between gamma-background of environment and indicators of electrolyte metabolism in patients with arterial hypertension depending on the variant of antihypertensive therapy

Abstract

Arterial hypertension and ischemic heart diseases continue to lead among cardiovascular diseases. In this regard, an importance of fixed-combination antihypertensive therapy is noted. There is an evidence that in years of high solar activity in a group of healthy persons and patients with arterial hypertension and ischemic heart disease reduces the quality of professional activity, cardiovascular diseases exacerbate so that some patients end up developing a heart attack or stroke. There was revealed the correlation between γ-background dynamics of the external environment (within the boundaries of the regional standards) and indicators of electrolyte metabolism in patients with arterial hypertension with different temperament and anxiety, which take an empirical variant of antihypertensive therapy or another variant targeted to the blockade of temperamental peculiarities of psychosomatic status, the most effective antihypertensive therapy was determined. When the power of γ-background in medium was increased, the concentration of potassium and magnesium in blood serum and erythrocytes decreased, but the concentration of sodium increased as the erythrocyte resistance decreased. These shifts are closely related to the increase in osmolar pressure of blood plasma, permeability of erythrocyte membranes for sodium ions, and hemolysis (low resistance of red blood cells, increased indirect bilirubin), and hepatocytes (increase of direct bilirubin). On the background of the targeted antihypertensive therapy the severity of the processes is low and nearly similar to those in healthy persons of corresponding temperament that is the evidence of high efficiency of targeted treatment option.