Correlation between αENaC gene T663A polymorphism and primary hypertension in Xinjiang Kazakans nationality

Abstract

Objective To investigate the correlation between αENaC gene T663A polymorphism and primary hypertension in Xinjiang Kazakans nationality. Methods In 257 primary hypertensive patients (group PH) and 259 normotensive control people (group NT) , α ENaC gene T663A polymorphism was detected by polymerase chain reaction and restriction fragment length polymorphism (PCR- RFLP). The distribution of genotype and allelic frequencies were analyzed between two groups. Multiple Logistic analysis was used to examine the correlation between the polymorphism and primary hypertension. Results In Xinjiang Kazakans nationality, the genotype distribution of α ENaC gene T663A was in Hardy-Weinberg equilibrium in both groups. Genotype distribution of AA, AG, GG in group PH was 16.34% (42/257) , 49.03% (126/257) , 34.63% (89/257) respectively and 15.06% (39/259) , 51.35% (133/259) , 33.59% (87/259) in group NT. The distribution of allelic frequencies of A and G was 40.86% (210/514), 59.14% (304/514) in group PH and 40.73%(211/518), 59.27%(307/518) in group NT respectively. There was no significant difference between two groups in distributed frequency of genotype or allele (P>0.05). There was no significant difference of blood pressure among three kinds of genotype (P>0.05). According to gender, BMI and age analysis, there was no significant difference between two groups in distributed frequence of genotype (P>0.05). The genotype of the T663A polymorphism was excluded as independent variables by multiple Logistic analysis (P>0.05). Conclusion αENaC gene T663A polymorphism is not correlated with primary hypertension in Xinjiang Kazakans nationality. Key words: Hypertension; Polymorphism, single nucleotide; Genotype; αENaC gene; Kazakans nationality