Association between type III prostatitis and vitamin D receptor gene Fok I polymorphism

Abstract

Objective To investigate the association between F/f single nucleotide polymorphism (SNP) of Fok Ⅰ in vitamin D receptor (VDR) gene and type Ⅲ prostatitis.Methods In 103 patients with type Ⅲ prostatitis (group A) and 100 control patients without prostatitis (group B),VDR gene Fok ⅠSNP was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).The distribution of genotype and allelic frequencies were analyzed.Multiple Logistic analysis was used to examine the association between SNP of Fok Ⅰ and type Ⅲ prostatitis.Results The genotype distribution of VDR gene FokⅠ was in Hardy-Weinberg equilibrium in both two groups.Genotype distribution of FF,Ff and ff in group A was 28％ (29/103),31％ (32/103) and 41％ (42/103) respectively,and 31％ (31/100),35％ (35/100),34％ (34/100) respectively in group B.There was significant difference between two groups in frequency distribution of ff genotype (P ＜ 0.05).The distribution of allelic frequencies of F and f was 44％ (90/206) and 56％ (116/206) in group A,and 49％ (97/200),51％ (103/200) in group B,respectively.There was significant difference between two groups in frequency distribution of allele (P ＜0.05).The FokⅠ polymorphism was an independent risk factor with type Ⅲ prostatitis by multiple Logistic analysis (P ＜ 0.05).Conclusion VDR FokⅠpolymorphisms are correlated with type Ⅲ prostatitis. Key words: Prostatitis; Single nucleotide polymorphism; Vitamin D receptor