Abstract
PurposeEvaluate best corrected visual acuity (BCVA), contrast sensitivity (SC), pattern electroretinogram (pERG), multifocal electroretinogram (mfERG), and multifocal visual evoked potentials (mfVEP) in multiple sclerosis (MS) and compare with healthy controls.MethodsFifty‐eight eyes were included: 14 of healthy controls and 44 of subjects with MS (of whom 17 presented a previous episode of optic neuritis). The BCVA ETDRS was recorded at 100% contrast, 2.5% and 1.25%, CS with CSV1000 test (at 3, 6, 9 and 12 cycles per degree) and Pelli Robson. The pERG, mfERG and mfVEP electrophysiology tests were performed with the Roland Consult's Reti‐port / scan device.ResultsPatients with MS showed a significant reduction of VA at 100% contrast (p = 0.013), 2.5% (p <0.001) and 1.25% (p = 0.008), CSV‐1000 was also affected at 3 (p = 0.017), 9 (p = 0.017), and 12 cycles per degree (p = 0.048), and also Pelli Robson (p <0.001). The mfERG showed in MS patients a significant affectation for amplitude and latency at the inferonasal and superonasal quadrants (p = 0.045 and 0.042 respectively), and the overall values of the mfPEV sown abnormalities at N1 and P1 amplitudes (p = 0.019 and p = 0.039, respectively).ConclusionsPatients with MS have a clear impairment of visual function in both psychophysical and electrophysiological tests.
Published Version
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