Correlation between electrocardiogram, myocardial biomarkers and left ventricular dysfunction in acute anterior ST segment elevation myocardial infarction

Abstract

To analyze the correlation between ST segment elevation, Q wave and peak biomarkers with left ventricular dysfunction in patients with acute anterior ST elevation myocardial infarction (STEMI). A total of 138 consecutive inpatients with acute anterior STEMI, left anterior descending branch as the convict vessel, from January 2009 to January 2012 in our hospital were enrolled in this study. They were divided into reperfusion (n = 92) and non-reperfusion group(n = 46). Clinical data, electrocardiogram, peak biomarkers, type B natriuretic peptide (BNP) were collected by physicians and the patients were followed up three months. The sum of the ST segments elevation, Q waves and Q wave leads in anterior STEMI were positive correlation with the Killip grades, myocardium biomarkers, BNP and left ventricle end diastolic diameters (LVEDD) [γ, 0.52-0.75, P < 0.01], while negative correlation with left ventricle ejection fraction (LVEF) [γ, -0.63--0.95, P < 0.01]. The sum of R wave altitude was negative correlation with myocardium biomarkers, BNP and LVEDD in three months after the onset of STEMI [γ, -0.48--0.79, P < 0.01], while positive correlation with LVEF [γ, 0.73-0.82, P < 0.01]. BNP, one of the best markers of left heart dysfunction, was found to be strongly negative correlation with LVEF in acute stage and three months after the onset of STEMI [γ , -0.92, -0.80, P < 0.01]. There are close correlations between electrocardiogram, myocardial biomarkers and left ventricular dysfunction in acute anterior ST segment elevation myocardial infarction, which may be strong predictors for the short-term prognosis.