Correlation between diabetic nephropathy and periodontal disease

Abstract

Objective To explore the relationship between diabetic nephropathy(DN) and periodontal disease.Methods 200 new hospitalized patients with type 2 diabetes were enrolled.Subjects were further divided into three groups according to the level of microalbuminuria(MAU):group A (normal albuminuria group):MAU ＜30 mg/24 h,group B (early-stage DN group):MAU 30 ～300 mg/24 h,group C (clinical DN group):MAU ＞300 mg/24 h.The clinical data and kidney function markers including serum creatinine (Scr),blood urea nitrogen(BUN) were collected,estimated glomerular filtration rate(eGFR) were calculated and the periodontal conditions including the periodontal pocket depth (PD),bleeding index (BI),clinical attachment loss (CAL) and tooth loss were detected.Results (1) BI,PD,CAL and tooth loss were increasing with MAU (P ＜ 0.001).(2) Logistic analysis showed that PD,GI and CAL were the independent risk factors of DN(P ＜0.05 or 0.01).(3) Scr was positively correlated with BI,PD,CAL and tooth loss (r =0.212,0.267,0.324,0.316 respectively,P ＜0.01);BUN was positively correlated with BI,PD,CAL and tooth loss (r =0.147,0.168,0.268,0.334 respectively,P ＜ 0.05) and eGFR was not correlated with BI (r =-0.137,P ＞ 0.05),but negatively correlated with PD,CAL and tooth loss (r =-0.213,-0.284,-0.339 respectively,P ＜ 0.01).Conclusion There might be a correlation between periodontal disease and DN.The periodontal disease and tooth loss could be an indicator for early detection of DN. Key words: Diabetic nephropathy; Periodontal disease ; Type 2 diabetes mellitus