Correlation between diabetic myocardial enzymes and diabetic microangiopathy

Abstract

Objective To investigate the clinical characteristics of serum myocardial enzymes spectrum and the correlation between them and diabetic microangiopathy. Methods The clinical data of all the patients with type 1 or type 2 diabetes mellitus during the first half year of 2015 were retrospectively analyzed. After ruled out the cases without detective indexes, 405 cases were selected. Marked group A and group B with patients combined cardiac enzyme rising and uncombined cardiac enzyme rising.To record the glycosylated hemoglobin, fasting blood glucose, fasting C peptide, lipids(cholesterol, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol), myocardial enzymes spectrum[aspartate aminotransfrrase(AST), lactate dehydrogenase (LDH) and it’s isoenzyme (LDH-1), and creatine kinase (CK) and it’s isoenzyme (CK-MB), α-hydroxybutyrate dehydrogenase (α-HBDH), ischemia modified albumin (IMA)], liver function, renal function, whether suffering from diabetic microangiopathy or other complications of the two groups. Results There were 116 patients with myocardial enzyme elevation, accounting for 28.6% of the total patients; Disease duration, age and the levels of AST, uric acid, cystatin C, retinol binding protein, creatinine clearance rate, the proportion of diabetic nephropathy (66.4% vs 27.3%) and diabetic retinopathy (65.5% vs 51.2%) had significant differences between the two groups (P<0.05). Conclusions There is correlation of the elevation of myocardial enzymes spectrum with diabetic microvascular disease. The LDH, LDH-1 and α-HBDH have greater reference value. By detecting myocardial enzymes, doctor can uncover the clue of diabetic microangiopathy including diabetic cardiomyopathy. Key words: Myocardial enzyme spectrum; Diabetic microvascular disease; Diabetic cardiomyopathy; Correlation