Correlation between Co-Therapy of Efavirenz-Based ART and Pregnancy among HIV-Positive Women on Hormonal Contraceptive Implants at TASO Tororo-Uganda: A Retrospective Review

Abstract

Background: We examined the association between EFV and non-EFV based ART regimens and pregnancy outcomes among women who were on HCI in a peri-urban HIV clinic in Tororo, Uganda. Methods: We reviewed and extracted routinely collected data from the TASO Tororo HIV clinic family planning register. All women >18 years of age and on ART who received HCI between January, 2012 and June, 2014 were included in the study. Results: Of the 148 women reviewed 9 (6.1%) conceived. All women who conceived were on an EFV-based regimen, while none of the women on non-EFV based regimens conceived (p=0.0003). Conclusion: We observed a significant association (p=0.0003) between HIV-positive HCI users on EFV-based ART regimens as compared to HIV-positive HCI users on non-EFV based ART regimens.