Abstract
Clinical studies have not fully assessed the potential impact of patients' biochemical indicators on the rate of positive for central venous catheter-tip microorganism culture (PCMC). Data were obtained from an online Medical Information Mart for Intensive Care IV database. Patients who were ≥18 years old and had central venous catheter-tip culture results without continuous renal replacement therapy were included in the study. A comparison of patient characteristics and their biochemical indicators was made between negative and positive culture results. A total of 5,323 patients were included in the analysis, including 612 positive (PCMC group) and 4,711 negative culture results (negative for central venous catheter tip catheter-tip microorganism culture [NCMC] group). The only influence factor on PCMC in this study was the serum creatinine (Scr) (odds ratio: 1.312, 95% confidence interval: 1.084-1.590, P=.005), according to a binary logistic regression analysis. The cut-off value of Scr was 3.25mg/dL. The prevalence of PCMC (27.1% vs 9.1%, P<.001) and Staphylococcus aureus (43.0% vs 18.6%, P<.001) for central venous catheter-tip culture results was much higher in patients with Scr≥3.25mg/dL than those Scr<3.25mg/dL. We used the large dataset collected from Medical Information Mart for Intensive Care IV to show that patients with Scr≥3.25mg/dL had an increased risk for PCMC.
Published Version
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