Abstract
Antiepileptic drugs (AEDs) are widely used to control seizure in children with epilepsy. These drugs are commonly used for a long time and are related with abnormalities of bone metabolism. This study investigates the correlation between calcium serum levels and bone mineral density (BMD) with duration of AEDs treatment. Thirty children with epilepsy on AEDs treatment for more than six months were evaluated. Data calcium serum, BMD, and duration of treatment were collected on the same time. Calcium serum and BMD was examined using immunoradiometric assay and dual energy X-ray, respectively. Pearson Correlation test was used to analyze the correlation between variable with significances if P value < 0.05. The subjects included 12 girls and 18 boys with mean age 8.5 years old. Duration of AEDs treatment, calcium serum levels, and BMD were 20.5 months, 9.35 (SD 0.32) mg/dl, and 0.81 (SD 0.07) g/cm2, respectively. It was moderate correlation between calcium serum and duration of treatment (r=-0.493; P=0.006). It was weak correlation between BMD and duration of treatment (r=-0.251; P=0.181). Duration of AEDs treatment in children with epilepsy correlated with calcium serum levels and BMD
Highlights
Antiepileptic drugs (AEDs) are widely used to control seizure in children with epilepsy
This study investigates the correlation between calcium serum levels and bone mineral density (BMD) with duration of AEDs treatment
Duration of AEDs treatment in children with epilepsy correlated with calcium serum levels and BMD
Summary
Antiepileptic drugs (AEDs) are widely used to control seizure in children with epilepsy. Antiepileptic drugs (AEDs) include sodium valproate (VPA), phenobarbitone (PB), phenytoin (DPH), and carbamazepine (CBZ) is widely used to control seizure in epilepsy. These drugs are commonly used for a long time. The drugs such as CBZ, DPH, and PB are known for inducing the activity of hepatic oxidase throughout the enzyme microsomal (P450) They influence the metabolism of mineral and bone by increasing vitamin D metabolism, that causing a deficiency of vitamin D (VDD).[4,5,6] This VDD inhibit intestinal calcium transport and absorption, that causing hypocalcaemia.[7] The other mechanism of the AEDs is act directly on bone cells that influence bone formation and resorption. The study evaluates the correlation of long-term uses of AEDs with calcium serum levels and BMD in epileptic children
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