Abstract
Asthma is a chronic immunological disorder of the lungs characterized by reversible airway obstruction, airway inflammation, and increased airway hyper responsiveness in response to provocative challenges. Objective: The aim of this study is to assess the level of serum vitamin D in patients with bronchial asthma and its correlation with disease severity. Methods: The present study, included 120 patients diagnosed as bronchial asthma. The patients were grouped on the basis of vitamin D sufficiency and vitamin D levels were correlated with disease severity and lung function. Results: Vitamin D deficiency was highly prevalent in asthmatic patients, and there was a direct and a significant relationship between serum vitamin D levels, severity of asthma, control of asthma, serum IgE levels, sputum eosinophils and lung function. Conclusions: Measuring serum levels of vitamin D followed by supplementation could be considered in the routine assessment of patients with bronchial asthma.
Highlights
Asthma is a chronic immunological disorder of the lungs characterized by reversible airway obstruction, airway inflammation, and increased airway hyper responsiveness in response to provocative challenges [1]
Based study suggests a strong relationship between serum concentrations of 25-hydroxyvitamin D, forced expiratory volume in 1s (FEV1), and forced vital capacity, as lower pulmonary function is associated with vitamin D deficiency [18]
Serum levels of vitamin D, pulmonary function tests, asthma control test score were analysed in 120 asthmatic patients who were divided into vitamin D sufficient and vitamin D insufficient group
Summary
Asthma is a chronic immunological disorder of the lungs characterized by reversible airway obstruction, airway inflammation, and increased airway hyper responsiveness in response to provocative challenges [1]. A correlation was seen in patients with asthma and COPD suggesting that the role of vitamin D may be more significant in these populations [17]. Based study suggests a strong relationship between serum concentrations of 25-hydroxyvitamin D, forced expiratory volume in 1s (FEV1), and forced vital capacity, as lower pulmonary function is associated with vitamin D deficiency [18]. The aim of this study was to prospectively investigate the relationship of vitamin D levels with markers of asthma severity and control in asthmatic patients
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